Three-dimensional structure of the human copper transporter hCTR1.
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The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper DistributionRole of copper transporters in platinum resistanceHow Mammalian Cells Acquire Copper: An Essential but Potentially Toxic MetalCharting the travels of copper in eukaryotes from yeast to mammalsStructural biology of copper traffickingCopper metallochaperonesCtr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domainIdentification of a receptor for an extinct virusA Plasmodium falciparum copper-binding membrane protein with copper transport motifsAn all-atom model of the structure of human copper transporter 1.Cryo-EM in the study of membrane transport proteins.C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implicationsTopologically conserved residues direct heme transport in HRG-1-related proteins.The puzzle posed by COMMD1, a newly discovered protein binding Cu(II).Brachypodium distachyon as a model system for studies of copper transport in cereal cropsThe Drosophila copper transporter Ctr1C functions in male fertilityThe role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatinUptake of compounds that selectively kill multidrug-resistant cells: the copper transporter SLC31A1 (CTR1) increases cellular accumulation of the thiosemicarbazone NSC73306The role of the methionines and histidines in the transmembrane domain of mammalian copper transporter 1 in the cellular accumulation of cisplatinHow copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1.Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stabilityThe role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.Lysosome-related organelles as mediators of metal homeostasis.Regulation of Cisplatin cytotoxicity by cu influx transporters.Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake.Upregulated copper transporters in hypoxia-induced pulmonary hypertension.The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sitesMolecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.A tetrahedral coordination of Zinc during transmembrane transport by P-type Zn(2+)-ATPases.β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.Metal transport across biomembranes: emerging models for a distinct chemistry.The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).Uncovering the Transmembrane Metal Binding Site of the Novel Bacterial Major Facilitator Superfamily-Type Copper Importer CcoA.Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase.Regulation of cation balance in Saccharomyces cerevisiaeCellular glutathione plays a key role in copper uptake mediated by human copper transporter 1.Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.
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P2860
Three-dimensional structure of the human copper transporter hCTR1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 24 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Three-dimensional structure of the human copper transporter hCTR1.
@en
Three-dimensional structure of the human copper transporter hCTR1.
@nl
type
label
Three-dimensional structure of the human copper transporter hCTR1.
@en
Three-dimensional structure of the human copper transporter hCTR1.
@nl
prefLabel
Three-dimensional structure of the human copper transporter hCTR1.
@en
Three-dimensional structure of the human copper transporter hCTR1.
@nl
P2093
P2860
P356
P1476
Three-dimensional structure of the human copper transporter hCTR1.
@en
P2093
Christopher J De Feo
Gnana S Siluvai
Ninian J Blackburn
Stephen G Aller
Vinzenz M Unger
P2860
P304
P356
10.1073/PNAS.0810286106
P407
P577
2009-02-24T00:00:00Z