Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats
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Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own HandsMolecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell DysfunctionMitochondrial regulation of β-cell function: maintaining the momentum for insulin releasePancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivoPancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell linesRpl13a small nucleolar RNAs regulate systemic glucose metabolism.Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways.Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells.Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis.A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress.Organoselenium compounds as mimics of selenoproteins and thiol modifier agents.Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants.Insights on Localized and Systemic Delivery of Redox-Based Therapeutics.
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P2860
Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ebselen treatment prevents isl ...... mass and function in ZDF rats
@en
Ebselen treatment prevents isl ...... mass and function in ZDF rats.
@nl
type
label
Ebselen treatment prevents isl ...... mass and function in ZDF rats
@en
Ebselen treatment prevents isl ...... mass and function in ZDF rats.
@nl
prefLabel
Ebselen treatment prevents isl ...... mass and function in ZDF rats
@en
Ebselen treatment prevents isl ...... mass and function in ZDF rats.
@nl
P2093
P2860
P356
P1433
P1476
Ebselen treatment prevents isl ...... mass and function in ZDF rats
@en
P2093
Ann V Hertzel
David A Bernlohr
Elizabeth Oseid
Jamie S Harmon
Jana Mahadevan
Melissa Lopez
R Paul Robertson
Sara N Vallerie
Susan Parazzoli
P2860
P304
P356
10.2337/DB13-0357
P407
P577
2013-06-25T00:00:00Z