Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. - Wikidata - awgldk - TriplyDB

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

http://www.wikidata.org/entity/Q37204210

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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys Project BioShield and the Biomedical Advanced Research Development Authority: A ten year progress report on meeting U.S. preparedness objectives for threat agents.Modeling the Effect of Herd Immunity and Contagiousness in Mitigating a Smallpox Outbreak.Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus.Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.Experimental infection of cynomolgus macaques (Macaca fascicularis) with aerosolized monkeypox virus.The genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America.A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge.Use of the Aerosol Rabbitpox Virus Model for Evaluation of Anti-Poxvirus Agents.Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases.Protection of rabbits and immunodeficient mice against lethal poxvirus infections by human monoclonal antibodies.Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice.Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route.A novel respiratory model of infection with monkeypox virus in cynomolgus macaques.Establishment of the black-tailed prairie dog (Cynomys ludovicianus) as a novel animal model for comparing smallpox vaccines administered preexposure in both high- and low-dose monkeypox virus challenges.Development of the small-molecule antiviral ST-246 as a smallpox therapeutic.Cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox.Development of ST-246® for Treatment of Poxvirus Infections.Utilizing diversity-oriented synthesis in antimicrobial drug discovery.Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease.Sequence of pathogenic events in cynomolgus macaques infected with aerosolized monkeypox virus.Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease.In vitro inhibition of monkeypox virus production and spread by Interferon-β.Intrabronchial inoculation of cynomolgus macaques with cowpox virus Remaining questions about clinical variola major.Update on new antivirals under development for the treatment of double-stranded DNA virus infections Inhalational monkeypox virus infection in cynomolgus macaques.Comparative pathology of smallpox and monkeypox in man and macaques.Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine.Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.Effects of postchallenge administration of ST-246 on dissemination of IHD-J-Luc vaccinia virus in normal mice and in immune-deficient mice reconstituted with T cells Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques.Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions.Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation Orthopoxvirus inhibitors that are active in animal models: an update from 2008 to 2012.Animal models of orthopoxvirus infection.A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012.Historical perspectives in the development of antiviral agents against poxviruses

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Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

http://www.wikidata.org/entity/Q37204210

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scientific article published on 06 April 2009

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Antimicrobial Agents and Chemotherapy

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Nonhuman primates are protecte ...... by the antiviral drug ST-246.

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Arthur Goff

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Carly Wlazlowski

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Chelsea M Byrd

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Dennis Hruby

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Eric Mucker

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Inger K Damon

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Jennifer Chapman

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John Huggins

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Josh Shamblin

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Kevin Karem

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P2860

Smallpox as a Biological Weapon

Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001.

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox.

characterization of acute-phase humoral immunity to monkeypox: use of immunoglobulin M enzyme-linked immunosorbent assay for detection of monkeypox infection during the 2003 North American outbreak.

The formation and function of extracellular enveloped vaccinia virus.

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

Smallpox: a potential agent of bioterrorism.

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2620-2625

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scholarly article

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10.1128/AAC.00021-09

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6

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53

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2009-04-06T00:00:00Z

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19349521

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2687232

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