Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.
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Cytotoxic CD4 T cells in antiviral immunityHIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesGastrointestinal tract and the mucosal macrophage reservoir in HIV infectionVaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replicationVaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protectionImplications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infectionConsensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cellsA DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responsesA vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II moleculesHIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge.Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides.Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid.Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.Immune mechanisms of HIV control.Pathogenesis and treatment of HIV infection: the cellular, the immune system and the neuroendocrine systems perspective.Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaquesLong-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses.Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection.HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.NK and CD4+ T cell cooperative immune responses correlate with control of disease in a macaque simian immunodeficiency virus infection model.Technical advance: liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human diseaseEarly HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b).Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controllerCo-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses.Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cellsPolyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates.A novel SIV gag-specific CD4(+)T-cell clone suppresses SIVmac239 replication in CD4(+)T cells revealing the interplay between antiviral effector cells and their infected targetsHLA/KIR restraint of HIV: surviving the fittestBiphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization.CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?Dendritic Cell Targeting Effectively Boosts T Cell Responses Elicited by an HIV Multiepitope DNA Vaccine.Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4+ T Cells.Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies.
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P2860
Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@en
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@nl
type
label
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@en
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@nl
prefLabel
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@en
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@nl
P2093
P2860
P50
P356
P1476
Gag- and Nef-specific CD4+ T c ...... ophages early after infection.
@en
P2093
Atsunobu Hiraoka
Chungwon Chung
Enrique J León
Jonah B Sacha
Juan P Giraldo-Vela
Lyle T Wallace
Nancy A Wilson
Nicholas J Maness
P2860
P304
P356
10.1073/PNAS.0813106106
P407
P577
2009-05-28T00:00:00Z