Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. - Wikidata - awgldk - TriplyDB

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

http://www.wikidata.org/entity/Q37219098

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Understanding the role of P2X7 in affective disorders-are glial cells the major players?P2X receptors as targets for the treatment of status epilepticus Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy The role of P2X7 receptors in a rodent PCP-induced schizophrenia model.Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Medicinal chemistry of adenosine, P2Y and P2X receptors.microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.Structural basis for subtype-specific inhibition of the P2X7 receptor.Ion channels and osteoarthritic pain: potential for novel analgesics.Central nervous system myeloid cells as drug targets: current status and translational challenges.The microglial ATP-gated ion channel P2X7 as a CNS drug target.Purinergic signaling in epilepsy.P2X receptors Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression.The role of microglial P2X7: modulation of cell death and cytokine release.Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine.Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.Probenecid directly impairs activation of the canine P2X7 receptor.Purinergic system in psychiatric diseases.Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease.Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.The P2X7 Receptor.Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.Microglial pannexin-1 channel activation is a spinal determinant of joint pain

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P2860

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

http://www.wikidata.org/entity/Q37219098

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.

@en

Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.

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type

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Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.

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Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.

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Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.

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British Journal of Pharmacology

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Pharmacological characterizati ...... eptor antagonist: JNJ-47965567

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Alan D Wickenden

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Anindya Bhattacharya

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Brian Lord

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Diane Nepomuceno

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Hong Ao

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Ian Fraser

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Leah Aluisio

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Michael A Letavic

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Natalie Welty

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Pascal Bonaventure

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P2860

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Signaling at purinergic P2X receptors

Altered cytokine production in mice lacking P2X(7) receptors

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients.

Neuromodulation by extracellular ATP and P2X receptors in the CNS.

Purinergic signalling in the nervous system: an overview.

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624-640

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10.1111/BPH.12314

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