Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
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Understanding the role of P2X7 in affective disorders-are glial cells the major players?P2X receptors as targets for the treatment of status epilepticusCritical Evaluation of P2X7 Receptor Antagonists in Selected Seizure ModelsP2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophyThe role of P2X7 receptors in a rodent PCP-induced schizophrenia model.Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosisPurinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Medicinal chemistry of adenosine, P2Y and P2X receptors.microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.Structural basis for subtype-specific inhibition of the P2X7 receptor.Ion channels and osteoarthritic pain: potential for novel analgesics.Central nervous system myeloid cells as drug targets: current status and translational challenges.The microglial ATP-gated ion channel P2X7 as a CNS drug target.Purinergic signaling in epilepsy.P2X receptorsRole of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression.The role of microglial P2X7: modulation of cell death and cytokine release.Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine.Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor AntagonistsRegulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.Probenecid directly impairs activation of the canine P2X7 receptor.Purinergic system in psychiatric diseases.Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease.Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.The P2X7 Receptor.Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.Microglial pannexin-1 channel activation is a spinal determinant of joint pain
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
@en
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
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type
label
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
@en
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
@nl
prefLabel
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
@en
Pharmacological characterizati ...... ptor antagonist: JNJ-47965567.
@nl
P2093
P2860
P356
P1476
Pharmacological characterizati ...... eptor antagonist: JNJ-47965567
@en
P2093
Alan D Wickenden
Anindya Bhattacharya
Brian Lord
Diane Nepomuceno
Ian Fraser
Leah Aluisio
Michael A Letavic
Natalie Welty
Pascal Bonaventure
P2860
P304
P356
10.1111/BPH.12314
P407
P577
2013-10-01T00:00:00Z