Turning a scorpion toxin into an antitumor miniprotein - Wikidata - awgldk - TriplyDB

Turning a scorpion toxin into an antitumor miniprotein

Turning a scorpion toxin into an antitumor miniprotein

http://www.wikidata.org/entity/Q37261088

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX Apamin as a novel template for structure-based rational design of potent peptide activators of p53 Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions Limitations of Peptide Retro-inverso Isomerization in Molecular Mimicry A Left-Handed Solution to Peptide Inhibition of the p53-MDM2 Interaction D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide An Ultrahigh Affinity d -Peptide Antagonist Of MDM2 Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor Differences in the transactivation domains of p53 family members: a computational study.Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold Beta-peptides with improved affinity for hDM2 and hDMX.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Centipede venoms as a source of drug leads.The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious Nanoparticle-conjugated animal venom-toxins and their possible therapeutic potential.Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.Constrained peptides as miniature protein structures In vitro determination of the efficacy of scorpion venoms as anti-cancer agents against colorectal cancer cells: a nano-liposomal delivery approach.A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation.Targeted delivery of a novel palmitylated D-peptide for antiglioblastoma molecular therapy.A stapled p53 helix overcomes HDMX-mediated suppression of p53.Evaluating the potential of a loop-extended scorpion toxin-like peptide as a protein scaffold.Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment.Small Scaffolds, Big Potential: Developing Miniature Proteins as Therapeutic Agents.Role of single disulfide linkages in the folding and activity of scyllatoxin-based BH3 domain mimetics.

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P2860

Turning a scorpion toxin into an antitumor miniprotein

http://www.wikidata.org/entity/Q37261088

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 18 September 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Turning a scorpion toxin into an antitumor miniprotein

@en

Turning a scorpion toxin into an antitumor miniprotein.

@nl

type

label

Turning a scorpion toxin into an antitumor miniprotein

@en

Turning a scorpion toxin into an antitumor miniprotein.

@nl

prefLabel

Turning a scorpion toxin into an antitumor miniprotein

@en

Turning a scorpion toxin into an antitumor miniprotein.

@nl

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Journal of the American Chemical Society

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Turning a scorpion toxin into an antitumor miniprotein

@en

P2093

Changqing Li

http://www.w3.org/2001/XMLSchema#string

Chong Li

http://www.w3.org/2001/XMLSchema#string

Davide Zella

http://www.w3.org/2001/XMLSchema#string

Guozhang Zou

http://www.w3.org/2001/XMLSchema#string

Juahdi Monbo

http://www.w3.org/2001/XMLSchema#string

Min Liu

http://www.w3.org/2001/XMLSchema#string

Wei-Yue Lu

http://www.w3.org/2001/XMLSchema#string

Weirong Yuan

http://www.w3.org/2001/XMLSchema#string

Wuyuan Lu

http://www.w3.org/2001/XMLSchema#string

P2860

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

p53 in health and disease

Tat peptide-mediated cellular delivery: back to basics.

Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer.

Transcellular protein transduction using the Tat protein of HIV-1.

P304

13546-13548

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scholarly article

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10.1021/JA8042036

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41

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130

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2008-09-18T00:00:00Z

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18798622

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3810402

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