Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsLegal but lethal: functional protein aggregation at the verge of toxicityImmobilization methods for the rapid total chemical synthesis of proteins on microtiter plates.The challenge of producing ubiquitinated proteins for structural studiesChemoenzymatic synthesis of bifunctional polyubiquitin substrates for monitoring ubiquitin chain remodeling.Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity.EMBO conference series: Chemical Biology 2014Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerizationInteraction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected PeptidesO-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's diseaseThe mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.Chemical Methods for Encoding and Decoding of Posttranslational ModificationsInhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.Breaking the limits of artificial ubiquitinationChemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.Using chemistry to investigate the molecular consequences of protein ubiquitylation.Models of α-synuclein aggregation in Parkinson's disease.Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins.Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.Accessing human selenoproteins through chemical protein synthesis.Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Chemical and semisynthetic approaches to study and target deubiquitinases.The Proteasome Inhibition Model of Parkinson's Disease.Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism.Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology.Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches.Aligator: A computational tool for optimizing total chemical synthesis of large proteins.Chemical Synthesis of Ubiquitin Chains.Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein.Synthesis of tumor necrosis factor α for use as a mirror-image phage display targetThe Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step.Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer.Designing cooperatively folded abiotic uni- and multimolecular helix bundles.
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Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@en
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@nl
type
label
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@en
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@nl
prefLabel
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@en
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@nl
P2093
P2860
P50
P356
P1476
Synthetic polyubiquitinated α- ...... egulating its pathophysiology.
@en
P2093
Ashraf Brik
Mahmood Haj-Yahya
Mirva Hejjaoui
Subramanian Vedhanarayanan Karthikeyan
Sudhir N Bavikar
Yifat Herman-Bachinsky
P2860
P304
17726-17731
P356
10.1073/PNAS.1315654110
P407
P577
2013-09-16T00:00:00Z