The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN
about
The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology EuroAnaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.ALK Fusions in a Wide Variety of Tumor Types Respond to Anti-ALK Targeted Therapy.Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome.Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation.ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.ALK in Neuroblastoma: Biological and Therapeutic Implications.
P2860
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P2860
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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2016年學術文章
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name
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN
@en
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN.
@nl
type
label
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN
@en
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN.
@nl
prefLabel
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN
@en
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN.
@nl
P2093
P2860
P50
P356
P1476
The ALK inhibitor PF-06463922 ...... by expression of ALK and MYCN
@en
P2093
A El Wakil
E R Tucker
G Umapathy
L S Danielson
R H Palmer
P2860
P304
P356
10.1242/DMM.024448
P577
2016-07-07T00:00:00Z