Toxicity testing in the 21st century: bringing the vision to life.
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Systems biology and biomarkers of early effects for occupational exposure limit settingAdvancing human health risk assessment: integrating recent advisory committee recommendationsInsulin resistance and environmental pollutants: experimental evidence and future perspectivesA 21st century paradigm for evaluating the health hazards of nanoscale materials?Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterialsToxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathwaysMeta-Analysis of Large-Scale Toxicogenomic Data Finds Neuronal Regeneration Related Protein and Cathepsin D to Be Novel Biomarkers of Drug-Induced ToxicityEthical and scientific considerations regarding animal testing and researchParadigm shift in toxicity testing and modeling.Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.A toxicology for the 21st century--mapping the road ahead.The future use of in vitro data in risk assessment to set human exposure standards: challenging problems and familiar solutions.Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage.Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.Issues in using human variability distributions to estimate low-dose riskThree dimensional cellular microarray platform for human neural stem cell differentiation and toxicology.Simulating quantitative cellular responses using asynchronous threshold Boolean network ensembles.Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects.The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.The human toxome projectPathway reporter genes define molecular phenotypes of human cellsToxicologic pathology in the 21st century.Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models.In vitro screening for population variability in chemical toxicity.Assessing the translatability of in vivo cardiotoxicity mechanisms to in vitro models using causal reasoning.Functional toxicogenomics: mechanism-centered toxicology.In silico toxicology - non-testing methods.Mechanistic research in aquatic toxicology: perspectives and future directionsAccelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshopFunctional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9.Identification and characterization of adverse effects in 21st century toxicologyComputational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract.A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In VitroThe MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials.Science and decisions: advancing toxicology to advance risk assessment.In vitro screening for population variability in toxicity of pesticide-containing mixturesEvaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? ...or a new edition of "the Red Book"?Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity.
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Toxicity testing in the 21st century: bringing the vision to life.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 12 December 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Toxicity testing in the 21st century: bringing the vision to life.
@en
Toxicity testing in the 21st century: bringing the vision to life.
@nl
type
label
Toxicity testing in the 21st century: bringing the vision to life.
@en
Toxicity testing in the 21st century: bringing the vision to life.
@nl
prefLabel
Toxicity testing in the 21st century: bringing the vision to life.
@en
Toxicity testing in the 21st century: bringing the vision to life.
@nl
P2860
P356
P1476
Toxicity testing in the 21st century: bringing the vision to life.
@en
P2860
P304
P356
10.1093/TOXSCI/KFN255
P577
2008-12-12T00:00:00Z