Multiple roles of HDAC inhibition in neurodegenerative conditions. - Wikidata - awgldk - TriplyDB

Multiple roles of HDAC inhibition in neurodegenerative conditions.

Multiple roles of HDAC inhibition in neurodegenerative conditions.

http://www.wikidata.org/entity/Q37407855

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Spinal muscular atrophy Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription Microbiota and Neurological Disorders: A Gut Feeling.Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder Small molecule inhibitors of zinc-dependent histone deacetylases Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future Therapeutic neuroprotective agents for amyotrophic lateral sclerosis The interplay between microRNAs and histone deacetylases in neurological diseases Huntington's disease: underlying molecular mechanisms and emerging concepts Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability Targeting histone deacetylases: perspectives for epigenetic-based therapy in cardio-cerebrovascular disease Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β Role of early life exposure and environment on neurodegeneration: implications on brain disorders Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2 The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes Identification of HDAC Inhibitors Using a Cell-Based HDAC I/II Assay General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae.Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy.Comparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families.What's New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment Epigenetics: an expanding new piece of the stroke puzzle Mechanisms of age-related cognitive change and targets for intervention: epigenetics.Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models.4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells.Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation

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Multiple roles of HDAC inhibition in neurodegenerative conditions.

http://www.wikidata.org/entity/Q37407855

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 21 September 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@en

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@nl

type

label

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@en

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@nl

prefLabel

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@en

Multiple roles of HDAC inhibition in neurodegenerative conditions.

@nl

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J.TINS.2009.06.002

P1433

Trends in Neurosciences

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Multiple roles of HDAC inhibition in neurodegenerative conditions

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Chi-Tso Chiu

http://www.w3.org/2001/XMLSchema#string

De-Maw Chuang

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Hyeon-Ju Kim

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Yan Leng

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P2860

HDAC6 is a microtubule-associated deacetylase

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

HDAC2 negatively regulates memory formation and synaptic plasticity.

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

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591-601

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scholarly article

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10.1016/J.TINS.2009.06.002

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11

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32

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2009-09-21T00:00:00Z

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26832866

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19775759

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neurodegeneration

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2771446

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