Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
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Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-ReviewCell-based screening: extracting meaning from complex data.Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain InjuryA high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteinsSerine 421 regulates mutant huntingtin toxicity and clearance in mice.Protein misfolding specifies recruitment to cytoplasmic inclusion bodiesAutophagy induction enhances TDP43 turnover and survival in neuronal ALS models.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionProteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase.The biology of proteostasis in aging and disease.Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering.A striatal-enriched intronic GPCR modulates huntingtin levels and toxicityDefining and measuring autophagosome flux—concept and realityNuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.In vivo kinetic approach reveals slow SOD1 turnover in the CNS.Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophyLevetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neuronsA Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal ProcessesTFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the ProteasomeMisfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.Pathology and function of nuclear amyloid. Protein homeostasis matters.Primary cilia and autophagic dysfunction in Huntington's disease.Walking the tightrope: proteostasis and neurodegenerative disease.SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Prion-Like Characteristics of Polyglutamine-Containing Proteins.Shaping proteostasis at the cellular, tissue, and organismal level.Recent insights on principles of synaptic protein degradationA thiol probe for measuring unfolded protein load and proteostasis in cells.Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Combating Parkinson's disease-associated toxicity by modulating proteostasis.Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy.A new method to measure autophagy flux in the nervous system.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.
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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@en
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@nl
type
label
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@en
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@nl
prefLabel
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@en
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.
@nl
P2093
P2860
P356
P1476
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
@en
P2093
Andrey S Tsvetkov
Benjamin A Shaby
D Michael Ando
Punita Sharma
Sami Barmada
Steven Finkbeiner
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1308
P577
2013-07-21T00:00:00Z