Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. - Wikidata - awgldk - TriplyDB

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

http://www.wikidata.org/entity/Q37509963

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Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review Cell-based screening: extracting meaning from complex data.Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Protein misfolding specifies recruitment to cytoplasmic inclusion bodies Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase.The biology of proteostasis in aging and disease.Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering.A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity Defining and measuring autophagosome flux—concept and reality Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65 Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.In vivo kinetic approach reveals slow SOD1 turnover in the CNS.Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.Pathology and function of nuclear amyloid. Protein homeostasis matters.Primary cilia and autophagic dysfunction in Huntington's disease.Walking the tightrope: proteostasis and neurodegenerative disease.SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Prion-Like Characteristics of Polyglutamine-Containing Proteins.Shaping proteostasis at the cellular, tissue, and organismal level.Recent insights on principles of synaptic protein degradation A thiol probe for measuring unfolded protein load and proteostasis in cells.Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Combating Parkinson's disease-associated toxicity by modulating proteostasis.Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy.A new method to measure autophagy flux in the nervous system.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.

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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

http://www.wikidata.org/entity/Q37509963

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 July 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@en

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@nl

type

label

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@en

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@nl

prefLabel

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@en

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

@nl

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Nature Chemical Biology

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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

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Andrey S Tsvetkov

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Benjamin A Shaby

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D Michael Ando

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Punita Sharma

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Sami Barmada

http://www.w3.org/2001/XMLSchema#string

Steven Finkbeiner

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P2860

Pulse-chase analysis of protein kinase C

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Aggresomes, inclusion bodies and protein aggregation

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

Automated microscope system for determining factors that predict neuronal fate.

Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light.

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586-592

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scholarly article

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10.1038/NCHEMBIO.1308

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9

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9

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Montserrat Arrasate

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2013-07-21T00:00:00Z

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250924799

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23873212

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3900497

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