Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer. - Wikidata - awgldk - TriplyDB

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

http://www.wikidata.org/entity/Q37521242

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Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1.Structural Implications for Selective Targeting of PARPs.Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.Transcriptional roles of PARP1 in cancer.The rise and fall of poly(ADP-ribose): An enzymatic perspective.DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.Parp-1genetic ablation inEla-mycmice unveils novel roles for Parp-1 in pancreatic cancer

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

http://www.wikidata.org/entity/Q37521242

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2013 nî lūn-bûn

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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0008-5472.CAN-13-1701

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Cancer Research

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Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

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Charles J Yeo

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Jamie L Planck

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Jamin D Steffen

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John M Pascal

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Jonathan R Brody

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Matthew J Schiewer

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Nikolai A Bildzukewicz

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Renee M Tholey

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The role of poly(ADP-ribose) in the DNA damage signaling network

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Selectivity and therapeutic inhibition of kinases: to be or not to be?

The role of PARP in DNA repair and its therapeutic exploitation

A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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31-37

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10.1158/0008-5472.CAN-13-1701

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1

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Karen E Knudsen

Marie-France Langelier

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2013-11-04T00:00:00Z

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258281109

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