Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
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Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 InhibitorsUse of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinicPARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesisNon-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivoPARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damageEpstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1.Structural Implications for Selective Targeting of PARPs.Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.Transcriptional roles of PARP1 in cancer.The rise and fall of poly(ADP-ribose): An enzymatic perspective.DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.Parp-1genetic ablation inEla-mycmice unveils novel roles for Parp-1 in pancreatic cancer
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P2860
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
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2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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name
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@en
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@nl
type
label
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@en
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@nl
prefLabel
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@en
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@nl
P2093
P2860
P50
P1433
P1476
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
@en
P2093
Charles J Yeo
Jamie L Planck
Jamin D Steffen
John M Pascal
Jonathan R Brody
Matthew J Schiewer
Nikolai A Bildzukewicz
Renee M Tholey
P2860
P356
10.1158/0008-5472.CAN-13-1701
P407
P577
2013-11-04T00:00:00Z