Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. - Wikidata - awgldk - TriplyDB

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

http://www.wikidata.org/entity/Q37587111

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Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions Exploring the accessible conformations of N-terminal acetylated α-synuclein Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease RepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles.Seeking a mechanism for the toxicity of oligomeric α-synuclein Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Conformational heterogeneity of α-synuclein in membrane.Novel therapeutic approaches in multiple system atrophy The many faces of α-synuclein: from structure and toxicity to therapeutic target.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding.Calcium signaling in Parkinson's disease.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy.Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo Synucleinopathies: common features and hippocampal manifestations.The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.Genetic Determinants of Parkinson's Disease: Can They Help to Stratify the Patients Based on the Underlying Molecular Defect?Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design.The cellular membrane as a mediator for small molecule interaction with membrane proteins.The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.The Oligomer Hypothesis in α-Synucleinopathy.Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.α-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons.A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.Current perspective of mitochondrial biology in Parkinson's disease.A novel therapeutic approach for synucleinopathies.Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide.Structural characteristics and membrane interactions of tandem α-synuclein oligomers.Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration.High-speed atomic force microscopy reveals structural dynamics of α-synuclein monomers and dimers

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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

http://www.wikidata.org/entity/Q37587111

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 February 2012

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

@en

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

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type

label

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

@en

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

@nl

prefLabel

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

@en

Role of α-synuclein penetratio ...... ms of oligomer pore formation.

@nl

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J.1742-4658.2012.08489.X

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Role of α-synuclein penetratio ...... ms of oligomer pore formation.

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Brian Spencer

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Igor F Tsigelny

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Leslie Crews

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Paula A Desplats

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Tania Gonzalez

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Wolfgang Wrasidlo

http://www.w3.org/2001/XMLSchema#string

Yuriy Sharikov

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P2860

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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1000-1013

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scholarly article

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10.1111/J.1742-4658.2012.08489.X

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Eliezer Masliah

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2012-02-27T00:00:00Z

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221753440

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