Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor
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Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune TherapyMelanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapseA phase I trial of panobinostat (LBH589) in patients with metastatic melanoma.Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cellsCytokines can counteract the inhibitory effect of MEK-i on NK-cell function.Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors.
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P2860
Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Aberrant apoptotic machinery confers melanoma dual resistance to BRAF
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Aberrant apoptotic machinery c ...... histone deacetylase inhibitor
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type
label
Aberrant apoptotic machinery confers melanoma dual resistance to BRAF
@nl
Aberrant apoptotic machinery c ...... histone deacetylase inhibitor
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prefLabel
Aberrant apoptotic machinery confers melanoma dual resistance to BRAF
@nl
Aberrant apoptotic machinery c ...... histone deacetylase inhibitor
@en
P2093
P2860
P1476
Aberrant apoptotic machinery c ...... histone deacetylase inhibitor
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P2093
Ali R Jazirehi
James S Economou
Ramin Nazarian
P2860
P577
2014-02-27T00:00:00Z