about
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptorMechanical regulation of T-cell functionsT cell antigen recognition at the cell membraneEpitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexSpecificity and completion time distributions of biochemical processesClonal anergy induced in a CD8+ hapten-specific cytotoxic T-cell clone by an altered hapten-peptide ligandTotal Internal Reflection with Fluorescence Correlation Spectroscopy: Nonfluorescent CompetitorsT-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APCIn vitro evolution of a T cell receptor with high affinity for peptide/MHC.The SCHOOL of nature: I. Transmembrane signaling.High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-lifeDissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.Ligand-receptor kinetics measured by total internal reflection with fluorescence correlation spectroscopy.Cross-reactivity in T-cell antigen recognition.Signaling cascades: escape from kinetic proofreadingBiochemical mechanisms of drug action: what does it take for success?Modulation of CD4 T cell function by soluble MHC II-peptide chimeras.Engineering improved T cell receptors using an alanine-scan guided T cell display selection systemA role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning.DNA specificity enhanced by sequential binding of protein monomers.Mathematical and computational models of immune-receptor signalling.T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytesCooperative enhancement of specificity in a lattice of T cell receptors.Immunology and mathematics: crossing the divide.Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurementsBreaking the affinity ceiling for antibodies and T cell receptorsStructural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligandsMolecular requirements for T cell recognition by a major histocompatibility complex class II-restricted T cell receptor: the involvement of the fourth hypervariable loop of the Valpha domain.CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex.Kinetics and extent of T cell activation as measured with the calcium signalA logical analysis of T cell activation and anergy.Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Kinetic discrimination in T-cell activation.
@en
Kinetic discrimination in T-cell activation.
@nl
type
label
Kinetic discrimination in T-cell activation.
@en
Kinetic discrimination in T-cell activation.
@nl
prefLabel
Kinetic discrimination in T-cell activation.
@en
Kinetic discrimination in T-cell activation.
@nl
P2093
P2860
P356
P1476
Kinetic discrimination in T-cell activation.
@en
P2093
H M McConnell
J D Rabinowitz
P2860
P304
P356
10.1073/PNAS.93.4.1401
P407
P577
1996-02-01T00:00:00Z