Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.
about
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerNucleases in homologous recombination as targets for cancer therapyMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairPhosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.EXD2 promotes homologous recombination by facilitating DNA end resectionGenotyping 1000 yeast strains by next-generation sequencing.Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombinationDNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegisAn S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nucleaseRelationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resectionThe Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiationReplication fork integrity and intra-S phase checkpoint suppress gene amplification.Mre11-Rad50 complex crystals suggest molecular calisthenics.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisionsRole for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extractsCtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Controlling DNA-end resection: a new task for CDKs.ATR phosphorylates SMARCAL1 to prevent replication fork collapseCoordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex.Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationVisualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instabilityResolution of complex ends by Nonhomologous end joining - better to be lucky than good?The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.Targeting homologous recombination-mediated DNA repair in cancer.A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex.The Shu complex is a conserved regulator of homologous recombination.Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resectionA role for the MRN complex in ATR activation via TOPBP1 recruitment.To trim or not to trim: progression and control of DSB end resectionActivation of DSB processing requires phosphorylation of CtIP by ATR.
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P2860
Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
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2010年學術文章
@zh-hant
name
Making the best of the loose e ...... double-strand break resection.
@en
Making the best of the loose e ...... double-strand break resection.
@nl
type
label
Making the best of the loose e ...... double-strand break resection.
@en
Making the best of the loose e ...... double-strand break resection.
@nl
prefLabel
Making the best of the loose e ...... double-strand break resection.
@en
Making the best of the loose e ...... double-strand break resection.
@nl
P2860
P1433
P1476
Making the best of the loose e ...... double-strand break resection.
@en
P2093
Tanya T Paull
P2860
P304
P356
10.1016/J.DNAREP.2010.09.015
P577
2010-11-02T00:00:00Z