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Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and developmentChallenges and advances in the assessment of the disposition of antibody-drug conjugatesChemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug ConjugatesA mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an antibody-drug conjugate (ADC) for treatment of metastatic breast cancer.Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program.High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting.Research and development in drug innovation: reflections from the 2013 bioeconomy conference in China, lessons learned and future perspectivesNear-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumorsMicrotubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma.Drug-conjugated antibodies for the treatment of cancer.Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma.Current Phase II antibody-drug conjugates for the treatment of lymphoid malignancies.Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug ConjugatesIn vivo biotransformations of antibody-drug conjugates.Bioanalytical approaches to assess the proteolytic stability of therapeutic fusion proteins.Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.Management of Multiple Myeloma with Second-Generation Antibody-Drug Conjugates.Harnessing the Immune System Against Leukemia: Monoclonal Antibodies and Checkpoint Strategies for AML.Evaluation of Targets for Maytansinoid ADC Therapy Using a Novel Radiochemical Assay.Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review.CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats.Intracellular Cleavable CpG Oligodeoxynucleotide-Antigen Conjugate Enhances Anti-tumor Immunity.Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.Pharmacokinetic Considerations for Antibody-Drug Conjugates against Cancer.Trastuzumab-modified DM1-loaded nanoparticles for HER2+ breast cancer treatment: an in vitro and in vivo study.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
ADME of antibody-maytansinoid conjugates
@en
type
label
ADME of antibody-maytansinoid conjugates
@en
prefLabel
ADME of antibody-maytansinoid conjugates
@en
P2860
P1433
P1476
ADME of antibody-maytansinoid conjugates
@en
P2093
Hans K Erickson
John M Lambert
P2860
P2888
P304
P356
10.1208/S12248-012-9386-X
P407
P577
2012-08-09T00:00:00Z
P5875
P6179
1040698161