SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. - Wikidata - awgldk - TriplyDB

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

http://www.wikidata.org/entity/Q38321332

about

Sox17 regulates insulin secretion in the normal and pathologic mouse β cell Sox17 regulates organ lineage segregation of ventral foregut progenitor cells Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics Minireview: microRNA function in pancreatic β cells.Sry-box (Sox) transcription factors in gastrointestinal physiology and disease.Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro.Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion The Yin and Yang of Sox proteins: Activation and repression in development and disease Nesfatin-1: a novel inhibitory regulator of food intake and body weight Sox6, jack of all trades: a versatile regulatory protein in vertebrate development Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling.Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas.Mechanisms of adult human β-cell in vitro dedifferentiation and redifferentiation.SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.Re-dicing the pancreatic β-cell: do microRNAs define cellular identity?The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.Is the effect of high fat diet on lipid and carbohydrate metabolism related to inflammation?

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SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

http://www.wikidata.org/entity/Q38321332

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-sg

2005年學術文章

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2005年學術文章

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2005年學術文章

@zh-hant

name

SOX6 attenuates glucose-stimul ...... n hyperinsulinemic obese mice.

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type

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SOX6 attenuates glucose-stimul ...... n hyperinsulinemic obese mice.

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prefLabel

SOX6 attenuates glucose-stimul ...... n hyperinsulinemic obese mice.

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Journal of Biological Chemistry

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SOX6 attenuates glucose-stimul ...... in hyperinsulinemic obese mice

@en

P2093

Aoi Uchida

http://www.w3.org/2001/XMLSchema#string

Go Hasegawa

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Haruhisa Iguchi

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Hiroto Ohguchi

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Kenta Magoori

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Koichi Sumi

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Makoto Naito

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Masashi Okamura

http://www.w3.org/2001/XMLSchema#string

Masashi Yanagisawa

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Noriaki Kojima

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P2860

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

Increased islet apoptosis in Pdx1+/- mice

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1

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37669-37680

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45

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280

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16148004

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