A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation PlansThe Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-LifeA transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injuryA multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicityEvaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells.Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.Competency of different cell models to predict human hepatotoxic drugs.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.Human biology-based drug safety evaluation: scientific rationale, current status and future challenges.Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes.Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.A new approach for the assessment of the toxicity of polyphenol-rich compounds with the use of high content screening analysis.Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays.A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk.Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines.Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
P2860
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P2860
A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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2013年论文
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2013年论文
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name
A correlation between the in v ...... cause liver injury in humans.
@en
A correlation between the in v ...... cause liver injury in humans.
@nl
type
label
A correlation between the in v ...... cause liver injury in humans.
@en
A correlation between the in v ...... cause liver injury in humans.
@nl
prefLabel
A correlation between the in v ...... cause liver injury in humans.
@en
A correlation between the in v ...... cause liver injury in humans.
@nl
P2093
P2860
P356
P1476
A correlation between the in v ...... o cause liver injury in humans
@en
P2093
Alison J Foster
Frida Gustafsson
Matthew H Bridgland-Taylor
Sunil Sarda
P2860
P304
P356
10.1093/TOXSCI/KFT223
P577
2013-10-01T00:00:00Z