Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
about
Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisMolecular basis of UG-rich RNA recognition by the human splicing factor TDP-43The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation siteGenetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsMutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentHu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.Characterization of the distal polyadenylation site of the ß-adducin (Add2) pre-mRNA.The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43Targeting RNA binding proteins involved in neurodegeneration.Microarray meta-analysis of RNA-binding protein functions in alternative polyadenylationGene targeting of mouse Tardbp negatively affects Masp2 expression.UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.A network of RNA and protein interactions in Fronto Temporal Dementia.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesisCytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.TDP-43 and FUS en route from the nucleus to the cytoplasm.Non-coding functions of alternative pre-mRNA splicing in development.Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein ClearanceLong non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.Transcription factor abundance controlled by an auto-regulatory mechanism involving a transcription start site switch.Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy.Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.Targeting TDP-43 in neurodegenerative diseases.Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation.TDP-43-The key to understanding amyotrophic lateral sclerosis.Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model.
P2860
Q26828357-9E0E7236-8FBC-43F0-AD42-DC3747F44889Q26863439-3C83AFDB-7C03-498C-B634-ECA430FA47C8Q27687574-DB427B73-0C49-469C-A8A4-B1FB9CEF0A78Q28082339-BF80914D-9BDA-468B-952B-1EDC88967F07Q28589988-3F01173A-DF3A-4915-9AD6-4A1F8C39657AQ30538184-C8F4BAD5-2BF4-4347-B3D3-E7EB092A755EQ30574944-D9759E26-B8C4-4A3A-95BA-12B2D8BEA7E7Q30575773-B60AFF38-036C-4B59-8F49-0D5DCFD9079DQ30848992-AD4A1D73-7DF7-43B1-A4B6-5530174D26F9Q33675871-97601A68-17FD-45A0-8986-D7C40C021D20Q34094693-6C1B0359-3006-433A-8B4E-CAE54F2B7060Q34509613-7571E991-65DC-42FD-B7A0-3D5CE72F433AQ34648489-303A11E6-6639-4046-B7D6-A423E1798B1DQ34904419-6BDADE66-C135-41D0-9B34-4814735E5295Q34954162-80BFA56C-02BC-4EA1-AC4B-BE65A760C661Q35118954-DBEAB411-7F35-47B6-8A51-3124AB97053FQ35150738-516FAFEE-6DC3-42C9-A5CD-8F5297EC7045Q35168278-430BC896-8D2B-4A0C-A9C5-772DC95F1191Q35194634-7DD2FE07-0279-4A07-B732-1D9CCEDBBFA3Q35501802-A582ADD2-A982-48E7-AAC3-8FFF99F1A9B4Q35875836-1872441A-7011-4B65-BEC0-B581A01A59EEQ36019592-9D686054-F06E-4FA6-98BC-5728F472DC39Q36336278-D9D7B69E-94C4-4EAD-9879-55674A2C693BQ36381437-D5F3E077-0F93-4CC5-BA10-C0B22BB81AE1Q36383297-8CCD408D-706E-49E1-9B0D-DDA3F5DAF61CQ36440463-3654C378-B9B2-45DB-8639-97ED61D6DC58Q36856336-B387ACA0-E83B-4232-8CFC-2D126D722D54Q37046148-BCAC3B01-6552-457C-909B-9845B1E8045DQ37076362-D9CBDB84-1F2D-4221-8249-C9FE0E9C051AQ37286990-1BCADE68-A205-4C28-A018-A9579E22D1ECQ37360742-EB7BB380-AFE0-489B-BED0-2B3AA4AB9D68Q37499894-00DC7731-68AD-4274-BF07-CC31B2F1BBF8Q37505760-1DBD226C-4D0B-4713-BE4F-9249F56EEFB3Q37606974-3B822F92-F33C-486D-9813-B33D5E7F0122Q37706412-112B9BAD-5548-4ECE-9223-FC3BF7CBBBFDQ38151263-900DB653-D19A-4112-8E30-F4E42737666AQ38197689-205493B0-FD49-4A99-9666-C7E816B4A7A9Q38257021-7ED2CCDC-4324-444A-B3B0-7E2F5AC64ED9Q38498576-AA5900C1-3EDC-48F2-B3AE-90F5775511C5Q38601956-EAAAF28B-069E-476C-B2CE-6E6D14781CB2
P2860
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@en
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@nl
type
label
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@en
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@nl
prefLabel
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@en
Autoregulation of TDP-43 mRNA ...... ernative polyA site selection.
@nl
P2860
P50
P356
P1433
P1476
Autoregulation of TDP-43 mRNA ...... ternative polyA site selection
@en
P2093
Francisco E Baralle
Sara Bembich
P2860
P304
P356
10.1101/GAD.194829.112
P577
2012-08-01T00:00:00Z