Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
about
Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctionsPolyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stressTargeting DNA Replication Stress for Cancer TherapyInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationRescuing stalled or damaged replication forksSynthetic lethality and cancer: cohesin and PARP at the replication forkInteraction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2Replication stress: getting back on trackRecovery from the DNA Replication CheckpointThe Causes and Consequences of Topological Stress during DNA ReplicationPreventing replication fork collapse to maintain genome integrityReplication stress in Mammalian cells and its consequences for mitosisNUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stabilityGenome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeastHuman HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling.Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.TOPOISOMERASE1α Acts through Two Distinct Mechanisms to Regulate Stele and Columella Stem Cell Maintenance.Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers.Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targetsSynthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecinPARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Poisoning of mitochondrial topoisomerase I by lamellarin DCellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.Causes and consequences of replication stress.Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.DNA structure-specific priming of ATR activation by DNA-PKcsNoncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phaseMec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends.Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.DNA2 drives processing and restart of reversed replication forks in human cells.
P2860
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P2860
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@en
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@nl
type
label
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@en
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@nl
prefLabel
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@en
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@nl
P2093
P2860
P50
P356
P1476
Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
@en
P2093
Andrea Cocito
Arnab Ray Chaudhuri
Raquel Herrador
Yoshitami Hashimoto
P2860
P2888
P304
P356
10.1038/NSMB.2258
P577
2012-03-04T00:00:00Z