Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.
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Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivoHydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cellsA vascular piece in the puzzle of adipose tissue dysfunction: mechanisms and consequences.Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.Antidiabetic and antioxidative effect of jiang tang xiao ke granule in high-fat diet and low-dose streptozotocin induced diabetic ratsIncreased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice.Arginine-directed glycation and decreased HDL plasma concentration and functionalityEndothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal.PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats.Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs.Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying MechanismsAn emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetesGlucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation.Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage.A novel PPARgamma agonist monascin's potential application in diabetes prevention.The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.Effect of diet-derived advanced glycation end products on inflammation.Intracellular methylglyoxal induces oxidative damage to pancreatic beta cell line INS-1 cell through Ire1α-JNK and mitochondrial apoptotic pathway.Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells.SEAP activity serves for demonstrating ER stress induction by glucolipotoxicity as well as testing ER stress inhibitory potential of therapeutic agents.Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises.Up-regulation of aldolase A and methylglyoxal production in adipocytes.The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.Phytoestrogen calycosin-7-O-β-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage.Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels.Dicarbonyl stress in clinical obesity.Antiglycative activity of sulforaphane: a new avenue to counteract neurodegeneration?Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis.Ice plant (Mesembryanthemum crystallinum) improves hyperglycaemia and memory impairments in a Wistar rat model of streptozotocin-induced diabetes.Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.
P2860
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P2860
Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@en
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@nl
type
label
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@en
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@nl
prefLabel
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@en
Chronic methylglyoxal infusion ...... abetes in Sprague-Dawley rats.
@nl
P2093
P2860
P356
P1433
P1476
Chronic methylglyoxal infusion ...... iabetes in Sprague-Dawley rats
@en
P2093
P2860
P304
P356
10.2337/DB10-0627
P407
P577
2011-02-07T00:00:00Z