Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation
about
The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membranePharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant ProteinsFolding efficiency is rate-limiting in dopamine D4 receptor biogenesisCys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerizationGEC1 interacts with the kappa opioid receptor and enhances expression of the receptorPhosphorylation-independent desensitization of GABA(B) receptor by GRK4Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedFunctional modulation of human delta opioid receptor by neuropeptide FF.Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expressionEngineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsPharmacological chaperoning: a primer on mechanism and pharmacologyGlutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.Trafficking and quality control of the gonadotropin releasing hormone receptor in health and diseaseA novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs.Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and functionUsing pharmacological chaperones to restore proteostasisA plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana.Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retentionChaperoning G protein-coupled receptors: from cell biology to therapeuticsIpsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.GnRH signaling, the gonadotrope and endocrine control of fertility.Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in traffickingAmino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptorHuman beta1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavageGABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsThe biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions.Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptorRescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonistCan intellectualism stifle scientific discovery?Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)Recent advances on the δ opioid receptor: from trafficking to function.Prolonged morphine treatment alters δ opioid receptor post-internalization traffickingMisrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance.Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.Chemical chaperones--a new concept in drug research.
P2860
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P2860
Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Ligands act as pharmacological ...... lta opioid receptor maturation
@en
Ligands act as pharmacological ...... ta opioid receptor maturation.
@nl
type
label
Ligands act as pharmacological ...... lta opioid receptor maturation
@en
Ligands act as pharmacological ...... ta opioid receptor maturation.
@nl
prefLabel
Ligands act as pharmacological ...... lta opioid receptor maturation
@en
Ligands act as pharmacological ...... ta opioid receptor maturation.
@nl
P2093
P2860
P921
P356
P1433
P1476
Ligands act as pharmacological ...... lta opioid receptor maturation
@en
P2093
André Laperrière
Jean-Pierre Morello
Mireille Hogue
Suparna Bhalla
Ulla E Petäjä-Repo
P2860
P304
P356
10.1093/EMBOJ/21.7.1628
P407
P577
2002-04-01T00:00:00Z