TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.
about
Targeting human telomeric G-quadruplex DNA and inhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2](4+)Single-molecule real-time detection of telomerase extension activityA Nitroxide-Tagged Platinum(II) Complex Enables the Identification of a DNA G-Quadruplex Binding ModeAssays for human telomerase activity: progress and prospects.Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitorsRHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancerMethods for investigating G-quadruplex DNA/ligand interactions.Experimental approaches to identify cellular G-quadruplex structures and functions.Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifsHuman telomerase inhibitors from microbial source.Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer.Visual detection of telomerase activity with a tunable dynamic range by using a gold nanoparticle probe-based hybridization protection strategy.The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties.Visualizing human telomerase activity with primer-modified Au nanoparticles.Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.Long-term nicotine exposure induces dysfunction of mouse endothelial progenitor cells.Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands.Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes.Targeting telomeric G-quadruplexes with the ruthenium(II) complexes [Ru(bpy)(2)(ptpn)](2+) and [Ru(phen)(2)(ptpn)](2+).Efficient Inhibition of Telomerase by Nickel-Salophen Complexes.Novel Oligopyrrole Carboxamide based Nickel(II) and Palladium(II) Salens, Their Targeting of Human G-Quadruplex DNA, and Selective Cancer Cell Toxicity.Octahedral ruthenium complexes selectively stabilize G-quadruplexes.Dinuclear ruthenium(II) complexes that induce and stabilise G-quadruplex DNA.Stabilization of human telomeric G-quadruplex and inhibition of telomerase activity by propeller-shaped trinuclear Pt(II) complexes.Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives.Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
P2860
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P2860
TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@en
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@nl
type
label
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@en
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@nl
prefLabel
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@en
TRAP-LIG, a modified telomere ...... inhibition by small molecules.
@nl
P2093
P356
P1476
TRAP-LIG, a modified telomere ...... inhibition by small molecules
@en
P2093
Anthony P Reszka
Mekala Gunaratnam
Monica Beltran
Stephen Neidle
P304
P356
10.1016/J.AB.2008.05.013
P407
P577
2008-05-17T00:00:00Z