about
5'-UTR RNA G-quadruplexes: translation regulation and targetingRAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersStructural studies of CNG repeatsAtomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseasesCrystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndromeA Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X SyndromeA dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.Crystallographic characterization of CCG repeatsStructural dynamics of double-helical RNAs composed of CUG/CUG- and CUG/CGG-repeatsCharacterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNAComputational investigation of RNA CUG repeats responsible for myotonic dystrophy 1Mechanistic determinants of MBNL activityMethods to enable the design of bioactive small molecules targeting RNA.Stabilization of RNA hairpins using non-nucleotide linkers and circularization.Oligonucleotide-based strategies to combat polyglutamine diseases.Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats.Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcriptsPolyglutamine repeats are associated to specific sequence biases that are conserved among eukaryotes.RNA-protein interactions in unstable microsatellite diseases.MBNL proteins and their target RNAs, interaction and splicing regulation.Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathologyAllele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.Features of modularly assembled compounds that impart bioactivity against an RNA target.Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.HIV-1 drug discovery: targeting folded RNA structures with branched peptides.Triplet repeat RNA structure and its role as pathogenic agent and therapeutic targetStructural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs)RNA Structures as Mediators of Neurological Diseases and as Drug Targets.In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA RepeatsIdentification of long non-coding transcripts with feature selection: a comparative study.The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structuresRNA toxicity in polyglutamine disorders: concepts, models, and progress of researchIdentifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular DiseasesStructural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.Using non-coding small RNAs to develop therapies for Huntington's disease.Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts.Trinucleotide repeats in human genome and exome.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Structural diversity of triplet repeat RNAs.
@en
type
label
Structural diversity of triplet repeat RNAs.
@en
prefLabel
Structural diversity of triplet repeat RNAs.
@en
P2093
P2860
P50
P356
P1476
Structural diversity of triplet repeat RNAs.
@en
P2093
Elzbieta Kierzek
Jacek Krol
Krzysztof Sobczak
Marta Olejniczak
Mateusz de Mezer
P2860
P304
12755-12764
P356
10.1074/JBC.M109.078790
P407
P577
2010-02-16T00:00:00Z