A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
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Progress toward overcoming hypoxia-induced resistance to solid tumor therapyMET inhibitors in combination with other therapies in non-small cell lung cancerThe role of MET receptor tyrosine kinase in non-small cell lung cancer and clinical development of targeted anti-MET agentsCharacterizing tyrosine phosphorylation signaling in lung cancer using SH2 profilingMET molecular mechanisms and therapies in lung cancerTGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling MechanismsDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyThe MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cellsAn orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cellsA chemical and phosphoproteomic characterization of dasatinib action in lung cancerMET receptor tyrosine kinaseAbsolute quantitation of Met using mass spectrometry for clinical application: assay precision, stability, and correlation with MET gene amplification in FFPE tumor tissue.Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer.Adipose stroma induces branching morphogenesis of engineered epithelial tubulesExpression of hepatocyte growth factor and its receptor c-Met in human pituitary adenomasA novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.Small-molecule Bax agonists for cancer therapy.Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in MedulloblastomaReceptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function.Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells.Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches.Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.Impact of MET targeting on tumor-associated angiogenesis and growth of MET mutations-driven models of liver cancer.The Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer.cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancerc-MET inhibition enhances the response of the colorectal cancer cells to irradiation in vitro and in vivoA high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of MetDNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.c-Met targeted therapy of cholangiocarcinomaMET as a target for treatment of chest tumorsEthnic differences and functional analysis of MET mutations in lung cancer.Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.MET pathway as a therapeutic target.Advances in preclinical small molecules for the treatment of NSCLC.Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism.MET targeted therapy for lung cancer: clinical development and future directionsMadecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon.
P2860
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P2860
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A selective small molecule inh ...... mouse lung cancer xenografts.
@en
type
label
A selective small molecule inh ...... mouse lung cancer xenografts.
@en
prefLabel
A selective small molecule inh ...... mouse lung cancer xenografts.
@en
P2093
P1433
P1476
A selective small molecule inh ...... mouse lung cancer xenografts.
@en
P2093
Andrey Khramtsov
Greg Karczmar
Jeremy T Hetzel
Neelu Puri
Ramasamy Jagadeeswaran
Salman Ahmed
Vidya Nallasura
P304
P356
10.1158/0008-5472.CAN-06-4416
P407
P50
P577
2007-04-01T00:00:00Z