Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. - Wikidata - awgldk - TriplyDB

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

http://www.wikidata.org/entity/Q40159491

about

Human inter-individual variability in metabolism and genotoxic response to zidovudine Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes Foetal loss and enhanced fertility observed in mice treated with Zidovudine or Nevirapine Genotoxic and Cytotoxic Effects of Antiretroviral Combinations in Mice Bone Marrow Inhibition of NF-κB activation sensitizes U937 cells to 3'-azido-3'-deoxythymidine induced apoptosis Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir.Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes.Effects of in utero antiretroviral exposure on mitochondrial DNA levels, mitochondrial function and oxidative stress.Tolerance of the newborn to antiretroviral drug exposure in utero.Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine.Molecular analysis of mitochondrial compromise in rodent cardiomyocytes exposed long term to nucleoside reverse transcriptase inhibitors (NRTIs).Defunct gadgets and changing times.Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.Next generation high throughput DNA damage detection platform for genotoxic compound screening.

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P2860

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

http://www.wikidata.org/entity/Q40159491

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Genotoxicity assessed by the c ...... child pairs to AZT or AZT-3TC.

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type

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Genotoxicity assessed by the c ...... child pairs to AZT or AZT-3TC.

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Genotoxicity assessed by the c ...... child pairs to AZT or AZT-3TC.

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Environmental and Molecular Mutagenesis

P1476

Genotoxicity assessed by the c ...... child pairs to AZT or AZT-3TC.

@en

P2093

Billy W Day

http://www.w3.org/2001/XMLSchema#string

Carol J Nesel

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Dale M Walker

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J Patrick O'Neill

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Miriam C Poirier

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Nancy A Wade

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Ofelia A Olivero

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Patricia A Escobar

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Quanxin Meng

http://www.w3.org/2001/XMLSchema#string

Richard D Day

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P2860

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

Individual variation in somatic mutations of the glycophorin-A gene in neonates in relation to pre-natal factors.

In vivo somatic mutations in humans: measurement and analysis.

In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus: phenotypic variation encompassing both gene-specific and chromosomal mechanisms.

The single cell gel electrophoresis assay (comet assay): a European review.

Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).

Nature of DNA lesions induced in human hepatoma cells, human colonic cells and human embryonic lung fibroblasts by the antiretroviral drug 3'-azido-3'-deoxythymidine.

P304

330-343

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scholarly article

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10.1002/EM.20285

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3-4

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48

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Elaine J Abrams

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2007-04-01T00:00:00Z

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6449186

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17358027

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