Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. - Wikidata - awgldk - TriplyDB

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

http://www.wikidata.org/entity/Q40190904

about

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle Pumilio facilitates miRNA regulation of the E2F3 oncogene Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers RB1: a prototype tumor suppressor and an enigma Molecular mechanisms underlying RB protein function Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway Drugging the addict: non-oncogene addiction as a target for cancer therapy Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes.Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root Arabidopsis RETINOBLASTOMA-RELATED is required for stem cell maintenance, cell differentiation, and lateral organ production.RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling.Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer.A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.miR-221/222 compensates for Skp2-mediated p27 degradation and is a primary target of cell cycle regulation by prostacyclin and cAMP Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein A kinase shRNA screen links LATS2 and the pRB tumor suppressor The rb pathway and cancer therapeutics miR than meets the eye.Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells.Retinoblastoma: Recent trends A mini review based on published literature.Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication.The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis A Skp2 autoinduction loop and restriction point control.Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.ΔNp63α represses anti-proliferative genes via H2A.Z deposition.RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

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Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

http://www.wikidata.org/entity/Q40190904

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Retinoblastoma protein and ana ...... perate during cell-cycle exit.

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type

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Retinoblastoma protein and ana ...... perate during cell-cycle exit.

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prefLabel

Retinoblastoma protein and ana ...... perate during cell-cycle exit.

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P1433

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P1433

Nature Cell Biology

P1476

Retinoblastoma protein and ana ...... perate during cell-cycle exit.

@en

P2093

Anders M Näär

http://www.w3.org/2001/XMLSchema#string

Frederick A Dick

http://www.w3.org/2001/XMLSchema#string

Marie K Classon

http://www.w3.org/2001/XMLSchema#string

Michael Rape

http://www.w3.org/2001/XMLSchema#string

Nicholas J Dyson

http://www.w3.org/2001/XMLSchema#string

Ulrich K Binné

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Wenyi Wei

http://www.w3.org/2001/XMLSchema#string

P2860

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

The retinoblastoma protein and cell cycle control

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Binding of pRB to the PHD protein RBP2 promotes cellular differentiation

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P304

225-232

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scholarly article

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10.1038/NCB1532

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2

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9

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William G. Kaelin

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2006-12-24T00:00:00Z

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6613524

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17187060

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