Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
about
The Timing of T Cell Priming and CyclingIL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.CD81 interacts with the T cell receptor to suppress signalingLineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
P2860
Q26776548-5B77694D-711C-4E23-979E-383A16F092ADQ34317840-43FE341A-6AE8-47F1-A278-2745630E019FQ34505331-4C2A86EA-52A1-429C-BD45-D5173171D7E3Q34831201-5A4962D8-54B6-4E34-B669-5653A260D195Q37330125-E212FE29-6C05-4718-8DCF-39B978E961E0Q41715654-443506E5-9D96-4567-A266-8A45A94A5F96Q44762315-031C5546-08D1-45A4-BBB2-60E0D447D8F2Q51461656-770F9368-9DA9-4065-A976-2BC57C1D7663Q51970307-F57E4CCC-7761-41D9-8D29-D4323CDF2392Q53562298-49239483-C1F3-4918-9DE4-41E3ED53355E
P2860
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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name
Coreceptor signal strength reg ...... n a physiologic in vivo model.
@en
type
label
Coreceptor signal strength reg ...... n a physiologic in vivo model.
@en
prefLabel
Coreceptor signal strength reg ...... n a physiologic in vivo model.
@en
P2093
P1476
Coreceptor signal strength reg ...... n a physiologic in vivo model.
@en
P2093
Alexander Grinberg
Alfred Singer
Amala S Alag
Batu Erman
François van Laethem
Oyvind Dahle
Paul E Love
Sophia D Sarafova
Susan O Sharrow
Terry I Guinter
P304
P356
10.4049/JIMMUNOL.177.10.6613
P407
P577
2006-11-01T00:00:00Z