Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A.
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Mechanisms of cancer cell killing by the adenovirus E4orf4 proteinViral infections and cell cycle G2/M regulationA RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRCThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunitLocalization and importance of the adenovirus E4orf4 protein during lytic infectionMicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressorsThe cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Neurospora crassa mat A-2 and mat A-3 proteins weakly interact in the yeast two-hybrid system and affect yeast growth.Yeast and apoptosis.Adenovirus replaces mitotic checkpoint controls.Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.Viral genes as oncolytic agents for cancer therapy.Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer.Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanismYND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis.NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell deathThe adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain.The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis.
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P2860
Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Toxicity of human adenovirus E ...... regulatory B subunit of PP2A.
@en
type
label
Toxicity of human adenovirus E ...... regulatory B subunit of PP2A.
@en
prefLabel
Toxicity of human adenovirus E ...... regulatory B subunit of PP2A.
@en
P2093
P2860
P356
P1433
P1476
Toxicity of human adenovirus E ...... regulatory B subunit of PP2A.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204693
P407
P577
2001-08-01T00:00:00Z
P5875
P6179
1042586548