An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias
about
RhoA: a therapeutic target for chronic myeloid leukemiaRegulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinaseBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayNucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicityTranscriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesThe PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activityc-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activationThe amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulationIdentification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contextsThe cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene productsThe Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actinc-Abl is required for development and optimal cell proliferation in the context of p53 deficiencyNuclear-cytoplasmic shuttling of C-ABL tyrosine kinaseModulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extensionZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis.Differences in structural elements of Bcr-Abl oncoprotein isoforms in Chronic Myelogenous Leukemia.Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of EnabledAbl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin.Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinaseAltered subcellular distribution of c-Abl in Alzheimer's disease.A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in miceThe Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL.Creating a niche in the cytoskeleton: Actin reorganization by a protein kinase.The extreme carboxyl terminus of v-Abl is required for lymphoid cell transformation by Abelson virus.From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and BeyondCytokine therapeutics: lessons from interferon alphaCentrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasmsTreatment of marrow stroma with interferon-alpha restores normal beta 1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1 alpha.The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity.Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.Treatment for chronic myelogenous leukemia: the long road to imatinibInduction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling.
P2860
Q21245760-1AF4B698-81F9-4CD7-9BA6-1A179ABC3E29Q24320206-1CDD3E42-5589-4FAC-86C1-B7A010E216ABQ24324144-2C72D48F-63A5-4255-8B1C-D342AD4AA22AQ24522838-A929A07C-BDF3-4FA6-9A64-03E38FD11C00Q24564193-65E41044-9394-4EF4-B525-1894F15D6CABQ24606662-E5740153-20D0-4250-B853-F502D33E7B1FQ24643842-985BA6F7-87C8-41C9-9460-8B293782DC28Q24649024-AF291110-D228-4BDA-943F-45AE77F8867DQ24651203-49C435B8-474E-4E6F-BCF7-FF09F3D1FEECQ24652254-FF500D0A-1DD6-45ED-A6B9-9B0B79125C48Q28508496-D1C24125-D28F-425D-AE27-CBFE7126D2F7Q28508973-AE700EE5-EA5A-4887-B5E5-EE6D66F9BB50Q28511871-D45FD987-A7B3-448A-B8F9-F3E70A652D7BQ28591266-0D6638E8-C14A-408B-A1D9-5A9257862E19Q28591494-44B64B9F-2A46-40D1-BA6E-2AE19BE85721Q28609080-5107FDE7-29EC-4F88-A706-129D761D8B12Q30008895-1635E3D6-C458-4FCB-969B-F29D1DDCFD1EQ30009436-CAB662CA-9F58-4128-B67B-8926489B22BFQ30010077-BCBBE341-0337-4270-B5C8-C7EEF6B7577BQ30176335-D0D24B80-31A6-447C-BF4E-9C369F0B428FQ30444235-1A3C7246-23F5-4F9E-A048-75ACFAF30545Q31095720-9A1D8A69-783B-42D1-B2B4-79E7D9CBEB67Q33429538-E7688E75-40EC-4128-9328-EBC151509E43Q33510153-796E9735-3B90-4518-92E2-11D7FC023336Q33720267-75E212BB-3848-40B5-BB65-24E34E019C39Q33828334-9035991F-D663-4D19-A97A-B371E3AD5FB5Q33952554-43C9B99E-7A64-4A13-B3B6-A6DD7A74B6E9Q34859191-4EA6E67D-0FFA-48F4-9179-30DF3D53E8C2Q34972855-2ECABFC0-33BC-44D8-AB6F-EE612CA2D016Q35033232-258A0CC5-1FA6-42BC-87B8-3CB830737710Q35127960-CC8A03C4-483D-4AC5-A6CF-A93AABC1CC8CQ35752819-0D348DEE-3B8E-43D2-8CB3-63F995B2F917Q36233735-AE9D37B1-B91C-43AA-87B8-E2D6E5A3E547Q36364351-3BF24195-66F9-4AAD-BFF1-2A85E618158EQ36555271-F551B69B-422C-45FC-8E75-3AFF082E0FCDQ36555282-E54DDBE7-C5F5-48FD-85BA-610F68E4C387Q36560556-C7CE524F-BD2E-4E2E-AB7A-794203E235E7Q36851400-A6CC9FB0-E9E6-4224-9921-5B674F194552Q36900105-6611D42E-88CF-413D-902F-6E93625E49EBQ36972619-D371BAB0-1CDD-4962-9CFB-F5AE5B0751BB
P2860
An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
An actin-binding function cont ...... osome-positive human leukemias
@en
type
label
An actin-binding function cont ...... osome-positive human leukemias
@en
prefLabel
An actin-binding function cont ...... osome-positive human leukemias
@en
P2860
P1433
P1476
An actin-binding function cont ...... osome-positive human leukemias
@en
P2093
J R McWhirter
P2860
P304
P407
P577
1993-04-01T00:00:00Z