Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma
about
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary glandHes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALLRole of STRAP in regulating GSK3β function and Notch3 stabilization.Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Notch Signaling in T-Cell Development and T-ALLNotch regulation of lymphocyte development and function.Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signalingNotch signaling in T-cell acute lymphoblastic leukemia.Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1Notch signaling in leukemia.A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing.Identification of novel Notch target genes in T cell leukaemia.Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.NOTCH3 Intracellular Domain Regulates Transcription
P2860
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P2860
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Pre-TCR-triggered ERK signalli ...... Notch3-induced T-cell lymphoma
@en
type
label
Pre-TCR-triggered ERK signalli ...... Notch3-induced T-cell lymphoma
@en
prefLabel
Pre-TCR-triggered ERK signalli ...... Notch3-induced T-cell lymphoma
@en
P2093
P2860
P356
P1433
P1476
Pre-TCR-triggered ERK signalli ...... Notch3-induced T-cell lymphoma
@en
P2093
Alberto Gulino
Antonio F Campese
Claudio Talora
Diana Bellavia
Harald von Boehmer
Isabella Screpanti
Luigi Frati
Manuela Groppioni
Monica Pascucci
Saula Checquolo
P2860
P304
P356
10.1038/SJ.EMBOR.7400013
P577
2003-10-17T00:00:00Z