Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415. - Wikidata - awgldk - TriplyDB

Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415.

Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415.

http://www.wikidata.org/entity/Q41778891

about

Efflux-mediated drug resistance in bacteria: an update New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?Efflux pumps as antimicrobial resistance mechanisms.Peptide deformylase inhibitors as potent antimycobacterial agents.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Drug forecast - the peptide deformylase inhibitors as antibacterial agents.Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy.Double trouble: medical implications of genetic duplication and amplification in bacteria.Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor Application of microarray and functional-based screening methods for the detection of antimicrobial resistance genes in the microbiomes of healthy humans.Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.Activity of LBM415 compared to those of 11 other agents against Haemophilus species.First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates.Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan.XCC2366, A Gene Encoding A Putative TetR Family Transcriptional Regulator, is Required for Acriflavin Resistance and Virulence of Xanthomonas campestris pv. campestris.Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC) during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae.Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor.

P2860

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P2860

Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415.

http://www.wikidata.org/entity/Q41778891

description

2005 nî lūn-bûn

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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Role of the AcrAB-TolC efflux ...... deformylase inhibitor LBM415.

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Role of the AcrAB-TolC efflux ...... deformylase inhibitor LBM415.

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Role of the AcrAB-TolC efflux ...... deformylase inhibitor LBM415.

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AAC.49.8.3129-3135.2005

P1433

Antimicrobial Agents and Chemotherapy

P1476

Role of the AcrAB-TolC efflux ...... deformylase inhibitor LBM415.

@en

P2093

Beat Weidmann

http://www.w3.org/2001/XMLSchema#string

Charles R Dean

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Denis M Daigle

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JoAnn L Dzink-Fox

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Karl E Dean

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Kathryn R Bracken

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Neil S Ryder

http://www.w3.org/2001/XMLSchema#string

Rakesh Jain

http://www.w3.org/2001/XMLSchema#string

Shubha Narayan

http://www.w3.org/2001/XMLSchema#string

Xiaoling Puyang

http://www.w3.org/2001/XMLSchema#string

P2860

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

Multidrug efflux pumps of gram-negative bacteria

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants

Multiple antibiotic resistance and efflux.

Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance.

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10.1128/AAC.49.8.3129-3135.2005

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8

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16048914

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1196275

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