Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens

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The role of epoxide hydrolases in health and disease.Cytotoxicity and Genotoxicity Assessment of Sandalwood Essential Oil in Human Breast Cell Lines MCF-7 and MCF-10A Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.

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Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens

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2004 nî lūn-bûn

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Detoxication strategy of epoxi ...... efinable genotoxic carcinogens

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Detoxication strategy of epoxi ...... efinable genotoxic carcinogens

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Detoxication strategy of epoxi ...... efinable genotoxic carcinogens

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P1476

Detoxication strategy of epoxi ...... efinable genotoxic carcinogens

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Franz Oesch

http://www.w3.org/2001/XMLSchema#string

Jan Georg Hengstler

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Michael Arand

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P2860

The alpha/beta hydrolase fold

Mechanism of microsomal epoxide hydrolase. Semifunctional site-specific mutants affecting the alkylation half-reaction.

Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate.

Kinetic and chemical mechanism of epoxide hydrolase.

Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes.

Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase.

Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks.

Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase.

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21-26

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scholarly article

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10.1080/15401420490426963

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2004-01-01T00:00:00Z

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24242575

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19330105

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2647822

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Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens

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P2860

P2860

Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P5875

P698

P932