Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.
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TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseSMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part B.Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice.Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasismiR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage.Gene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathwayAttenuation of the progression of articular cartilage degeneration by inhibition of TGF-β1 signaling in a mouse model of osteoarthritisThe Role of miRNAs in Cartilage Homeostasis.Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage.Mechanobiology of TGFβ signaling in the skeleton.Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-β.Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytesDifferential roles of TGF-β signalling in joint tissues during osteoarthritis development.Osteoarthritis: toward a comprehensive understanding of pathological mechanism.Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis.Smad4 regulates growth plate matrix production and chondrocyte polarity.Insights from human genetic studies into the pathways involved in osteoarthritis.TGFβ signaling in cartilage development and maintenance.TGF-β signal transduction pathways and osteoarthritis.Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.Generation of Immortalized Equine Chondrocytes With Inducible Sox9 Expression Allows Control of Hypertrophic Differentiation.Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis.Expression profiling and functional implications of a set of zinc finger proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in primary osteoarthritic articular chondrocytes.DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.Yougui Pills Attenuate Cartilage Degeneration via Activation of TGF-β/Smad Signaling in Chondrocyte of Osteoarthritic Mouse Model.Down-regulation of microRNA-216b inhibits IL-1β-induced chondrocyte injury by up-regulation of Smad3.Altered expression of microRNA-98 in IL-1β-induced cartilage degradation and its role in chondrocyte apoptosis.The molecular mechanism of treating osteoarthritis with dipsacus saponins by inhibiting chondrocyte apoptosis.Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese.MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells.Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes.MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway.Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice.
P2860
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P2860
Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Chondrocyte-intrinsic Smad3 re ...... ge and prevent osteoarthritis.
@en
type
label
Chondrocyte-intrinsic Smad3 re ...... ge and prevent osteoarthritis.
@en
prefLabel
Chondrocyte-intrinsic Smad3 re ...... ge and prevent osteoarthritis.
@en
P2093
P2860
P356
P1476
Chondrocyte-intrinsic Smad3 re ...... age and prevent osteoarthritis
@en
P2093
Carol G Chen
Daniel Thuillier
Emily N Chin
P2860
P304
P356
10.1002/ART.34566
P577
2012-10-01T00:00:00Z