about
Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamilyDiverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 productionChronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damageLysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane reTrehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathologyOverlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Substrate-targeting gamma-secretase modulatorsPossible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulatorsIntracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.Short Aβ peptides attenuate Aβ42 toxicity in vivo.Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.Medicine. Avoiding unintended toxicity.Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity.Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins.
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Thomas Kukar
@ast
Thomas Kukar
@en
Thomas Kukar
@es
Thomas Kukar
@nl
Thomas Kukar
@sl
type
label
Thomas Kukar
@ast
Thomas Kukar
@en
Thomas Kukar
@es
Thomas Kukar
@nl
Thomas Kukar
@sl
prefLabel
Thomas Kukar
@ast
Thomas Kukar
@en
Thomas Kukar
@es
Thomas Kukar
@nl
Thomas Kukar
@sl
P106
P108
P1153
6602442843
P21
P31
P496
0000-0002-3750-6262