about
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cellsThe Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus.Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activityCdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cellsCyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase IIHyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase IIp27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.Xpd/Ercc2 regulates CAK activity and mitotic progression.Molecular cloning of the Drosophila homologue of the rat ribosomal protein L11 gene.The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity
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Q28482509-7859BD3A-5446-4347-80A5-A6E389074E51Q30193046-DB49CEEC-1003-425B-9A4A-B3BC5F154FC4Q30479187-6D323AF4-D414-48A3-93AD-D4B3C3D75CCFQ34080819-062EF14E-9F72-4D9D-867D-C11AD58C4856Q35190030-9369059B-74FB-4685-81CB-F8029A31FA60Q35765888-5DF61AD4-9B15-4700-8E47-7F79D4FB5B1CQ36210855-CF2EE23F-1B94-4B4C-BC5B-AB553970402EQ37098110-FE16DC94-4C31-4DBD-B9EE-211C8228FD0EQ37103512-F6E78508-98BB-4303-BFAC-BBEAE896B9E7Q37369481-5E66AABC-EB39-435C-84BC-D9261F1419E9Q39814573-4644BBCC-EB49-4A4B-8702-3C72DB260B90Q42277847-6E3D3B80-F10F-41B9-875C-C61F186BBB05Q42444468-64509885-FCAE-4CDE-A1AA-809E51FDB3DAQ52209486-EEFD0500-6663-4F91-9A01-460FED6EB962Q82904836-928C65DB-065D-4C40-8B00-C2602390222C
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Stéphane Larochelle
@ast
Stéphane Larochelle
@en
Stéphane Larochelle
@es
Stéphane Larochelle
@nl
Stéphane Larochelle
@sl
type
label
Stéphane Larochelle
@ast
Stéphane Larochelle
@en
Stéphane Larochelle
@es
Stéphane Larochelle
@nl
Stéphane Larochelle
@sl
prefLabel
Stéphane Larochelle
@ast
Stéphane Larochelle
@en
Stéphane Larochelle
@es
Stéphane Larochelle
@nl
Stéphane Larochelle
@sl
P1053
D-3662-2012
P106
P21
P31
P3829
P496
0000-0002-4594-4342