Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. - Wikidata - awgldk - TriplyDB

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

http://www.wikidata.org/entity/Q43069114

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Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases External and internal triggers of cell death in yeast Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast.Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.The ceramide-activated protein phosphatase Sit4p controls lifespan, mitochondrial function and cell cycle progression by regulating hexokinase 2 phosphorylation.Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner Developmentally regulated sphingolipid degradation in Leishmania major Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene.The yeast sphingolipid signaling landscape.Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.Phosphatidylethanolamine positively regulates autophagy and longevity Oxidative stress and programmed cell death in yeast.Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants.Sphingolipids and lifespan regulation.Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Apoptosis in yeast: triggers, pathways, subroutines.Sphingolipids and mitochondrial function, lessons learned from yeast Roles for sphingolipids in Saccharomyces cerevisiae.Genome-scale studies of aging: challenges and opportunities Lipids and cell death in yeast.Sphingolipids and mitochondrial function in budding yeast.Assessment of crosstalks between the Snf1 kinase complex and sphingolipid metabolism in S. cerevisiae via systems biology approaches.Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.Eco-evolutionary feedbacks drive species interactions.Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast.Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism.The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions.Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.Oxidative stress during aging of the yeast in a stationary culture and its attenuation by antioxidants.The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy.

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Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

http://www.wikidata.org/entity/Q43069114

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2007 nî lūn-bûn

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Isc1p plays a key role in hydr ...... of iron levels and apoptosis.

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Isc1p plays a key role in hydr ...... of iron levels and apoptosis.

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Isc1p plays a key role in hydr ...... of iron levels and apoptosis.

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Isc1p plays a key role in hydr ...... of iron levels and apoptosis.

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Molecular Biology of the Cell

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Isc1p plays a key role in hydr ...... of iron levels and apoptosis.

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Manuela Côrte-Real

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Maria A Amorim

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Marta Marques

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Pedro Rodrigues

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Teresa Almeida

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P2860

Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster

FunSpec: a web-based cluster interpreter for yeast.

ArrayExpress--a public repository for microarray gene expression data at the EBI

The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake.

The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.

Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo.

Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae.

Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.

Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.

Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae.

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865-876

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10.1091/MBC.E07-06-0604

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3

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19

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Pedro Moradas-Ferreira

Dominik Mojzita

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2007-12-27T00:00:00Z

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18162582

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2262964

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