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Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...X-ray crystal structure of the streptococcal specific phage lysin PlyC.The N terminus of the serpin, tengpin, functions to trap the metastable native stateThe REFOLD database: a tool for the optimization of protein expression and refolding.Conformational changes during pore formation by the perforin-related protein pleurotolysinBrinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron densityThe structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor familyA structural basis for loop C-sheet polymerization in serpinsStructural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseStructure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind SubstratesS1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue DestructionThe X-ray crystal structure of full-length human plasminogenReconciling the Structural Attributes of Avian AntibodiesHigh resolution structure of cleaved Serpin 42 Da from Drosophila melanogasterDefining the interaction of perforin with calcium and the phospholipid membraneThe 2.6 A structure of antithrombin indicates a conformational change at the heparin binding siteThe yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum.Structure of the poly-C9 component of the complement membrane attack complexIL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transductionStructural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid MembranesThe serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclatureCell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized MicePredicting giant transmembrane β-barrel architecture.The MACPF/CDC family of pore-forming toxins.Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.Automatic generation of protein structure cartoons with Pro-origami.The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens.Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.Determination of the P1', P2' and P3' subsite-specificity of factor Xa.Managing and mining protein crystallization data.IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates.Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.Federated repositories of X-ray diffraction images.Conformational change in the chromatin remodelling protein MENTMUSTANG-MR structural sieving server: applications in protein structural analysis and crystallographyMrGrid: a portable grid based molecular replacement pipelineThe type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.
P50
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P50
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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James C. Whisstock
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P106
P1153
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P21
P2456
P31
P496
0000-0003-4200-5611