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The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length proteinA gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibitionInhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum ProliferationInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyThe multiple cellular functions of the oncoprotein Golgi phosphoprotein 3The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptorSorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosisInventory of the proteins in Neisseria meningitidis serogroup B strain MC58.Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis.Identification of small molecule inhibitors of the Aurora-A/TPX2 complexActivation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains.GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.Structural basis of Sorcin-mediated calcium-dependent signal transductionInhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.Polyamine-trypanothione pathway: an update.Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput dockingBinding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cellsMetal- and metalloid-containing drugs for the treatment of trypanosomatid diseases.Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.Information transfer in the penta-EF-hand protein sorcin does not operate via the canonical structural/functional pairing. A study with site-specific mutants.Green tea catechins can bind and modify ERp57/PDIA3 activity.Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes.Molecular characterization of nitrite reductase gene (aniA) and gene product in Neisseria meningitidis isolates: is aniA essential for meningococcal survival?Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy.Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits.The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity.Identification of chalcone-based antileishmanial agents targeting trypanothione reductaseCooperative Oxygen Binding toScapharca inaequivalvisHemoglobin in the CrystalQuality-based model for Life Sciences research guidelines
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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type
label
Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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prefLabel
Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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Gianni Colotti
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P106
P1153
6602135968
P21
P31
P496
0000-0002-9913-0635