Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene.
about
Protein phosphatase 2A interacts with and directly dephosphorylates RelAB56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERKThe tumor suppressor PP2A Abeta regulates the RalA GTPaseCharacterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolutionThe FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinaseTargeting protein serine/threonine phosphatases for drug developmentThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceProtein Phosphatase 2A as a Therapeutic Target in Acute Myeloid LeukemiaLB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potentialMechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylationStructural Basis of PP2A Inhibition by Small t AntigenPP2A: The Wolf in Sheep's Clothing?Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit geneProtein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in XenopusThe protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiationTranscriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene.Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development.Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer.Physiological regulation of Akt activity and stability.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2ATwo conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domainsViewing serine/threonine protein phosphatases through the eyes of drug designersHuman cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Phosphatases: the new brakes for cancer development?PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effectsRestricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive functionNitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.The emerging role of the PI3-K-Akt pathway in prostate cancer progression.PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerPatient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway
P2860
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P2860
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@en
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@nl
type
label
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@en
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@nl
prefLabel
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@en
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@nl
P2093
P2860
P356
P1433
P1476
Disruption of protein phosphat ...... s in the A alpha subunit gene.
@en
P2093
P2860
P2888
P356
10.1038/SJ.ONC.1204059
P407
P577
2001-01-01T00:00:00Z
P5875
P6179
1042334898