Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners.
about
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspasesInteraction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein † ‡An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.The mechanism of peptide-binding specificity of IAP BIR domains.Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide.Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain.Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAPDesign of small-molecule peptidic and nonpeptidic Smac mimetics.IAP-targeted therapies for cancer.Small-molecule pan-IAP antagonists: a patent review.Targeting inhibitor of apoptosis proteins for therapeutic intervention.Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies.Inhibitor-based affinity probes for the investigation of JAK signaling pathways.Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).Pro-apoptotic cell death genes, hid and reaper, from the tephritid pest species, Anastrepha suspensa.Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.Development of Peptidomimetics Targeting IAPsActivation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules.The 'unique key' feature of the Iap-binding motifs in RHG proteins.Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.DNA-Triggered Synthesis and Bioactivity of Proapoptotic Peptides
P2860
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P2860
Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Molecular targeting of inhibit ...... s of natural binding partners.
@en
Molecular targeting of inhibit ...... s of natural binding partners.
@nl
type
label
Molecular targeting of inhibit ...... s of natural binding partners.
@en
Molecular targeting of inhibit ...... s of natural binding partners.
@nl
prefLabel
Molecular targeting of inhibit ...... s of natural binding partners.
@en
Molecular targeting of inhibit ...... s of natural binding partners.
@nl
P2093
P356
P1433
P1476
Molecular targeting of inhibit ...... s of natural binding partners.
@en
P2093
Aislyn D Wist
Arun Wiita
Catherine M Cresson
George L McLendon
Jijie Chai
Maria Carrell
Martin A Case
Martin F Semmelhack
Philip A Albiniak
Rachael A Kipp
P304
P356
10.1021/BI0121454
P407
P50
P577
2002-06-01T00:00:00Z