Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.
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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersAndrogen biosynthesis in castration-resistant prostate cancerRv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenaseCloning and characterization of uronate dehydrogenases from two pseudomonads and Agrobacterium tumefaciens strain C58Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans.The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer.Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1Regulation of human 3β-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche.Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis.Mitochondrial 3β-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space.Lipid-mediated unfolding of 3β-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity.3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.Minireview: Androgen metabolism in castration-resistant prostate cancer.Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanismsStructural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells.Maternal dietary restriction during the periconceptional period in normal-weight or obese ewes results in adrenocortical hypertrophy, an up-regulation of the JAK/STAT and down-regulation of the IGF1R signaling pathways in the adrenal of the postnataHuman 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics.Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse.The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni.
P2860
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P2860
Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Structure/function relationshi ...... alysis of the type 1 activity.
@en
Structure/function relationshi ...... alysis of the type 1 activity.
@nl
type
label
Structure/function relationshi ...... alysis of the type 1 activity.
@en
Structure/function relationshi ...... alysis of the type 1 activity.
@nl
prefLabel
Structure/function relationshi ...... alysis of the type 1 activity.
@en
Structure/function relationshi ...... alysis of the type 1 activity.
@nl
P2093
P2860
P356
P1476
Structure/function relationshi ...... alysis of the type 1 activity.
@en
P2093
Byron R Spencer
J Ian Mason
James L Thomas
Stacey Brandt
Wendy Norris
P2860
P304
42795-42801
P356
10.1074/JBC.M208537200
P407
P577
2002-08-29T00:00:00Z