Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.

Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.

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Q44155944

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TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response Free cysteine modulates the conformation of human C/EBP homologous protein Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress Molecular cloning, characterization and regulation of two different NADH-glutamate synthase cDNAs in bean nodules.Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.Cell cycle-dependent recruitment of polycomb proteins to the ASNS promoter counteracts C/ebp-mediated transcriptional activation in Bombyx mori.Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation.ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation.Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription.Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.Control of mammalian gene expression by amino acids, especially glutamine.Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells.Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation.DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte.Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress.A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation.Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter.Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells.Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells.

P2860

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P2860

Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.

Item

http://www.wikidata.org/entity/Q44155944

description

2002 nî lūn-bûn

@nan

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

2002年學術文章

@zh-hant

name

Differences in the molecular m ...... the unfolded protein response.

@en

Differences in the molecular m ...... the unfolded protein response.

@nl

type

Item

label

Differences in the molecular m ...... the unfolded protein response.

@en

Differences in the molecular m ...... the unfolded protein response.

@nl

prefLabel

Differences in the molecular m ...... the unfolded protein response.

@en

Differences in the molecular m ...... the unfolded protein response.

@nl

P1476

Differences in the molecular m ...... the unfolded protein response.

@en

P2093

Alain Bruhat

http://www.w3.org/2001/XMLSchema#string

Andreas M Reimold

http://www.w3.org/2001/XMLSchema#string

Can Zhong

http://www.w3.org/2001/XMLSchema#string

Julien Averous

http://www.w3.org/2001/XMLSchema#string

Michael S Kilberg

http://www.w3.org/2001/XMLSchema#string

Pierre Fafournoux

http://www.w3.org/2001/XMLSchema#string

Valérie Carraro

http://www.w3.org/2001/XMLSchema#string

P2860

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Isolation, characterization and chromosomal localization of the human GADD153 gene

Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6.

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

Regulated translation initiation controls stress-induced gene expression in mammalian cells

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

P304

48107-48114

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P31

scholarly article

P356

10.1074/JBC.M206149200

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

277

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P577

2002-09-25T00:00:00Z

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P698

12351626

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Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.

about

P2860

P2860

Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698