Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.
about
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathCharacterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter geneThe p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOPRole of the repressor JDP2 in the amino acid-regulated transcription of CHOPActivating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseFree cysteine modulates the conformation of human C/EBP homologous proteinIntrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stressMolecular cloning, characterization and regulation of two different NADH-glutamate synthase cDNAs in bean nodules.Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathwayTranscriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.Cell cycle-dependent recruitment of polycomb proteins to the ASNS promoter counteracts C/ebp-mediated transcriptional activation in Bombyx mori.Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation.ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation.Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription.Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathwayDifferential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during theTranscription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.Control of mammalian gene expression by amino acids, especially glutamine.Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells.Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation.DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte.Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress.A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation.Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter.Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells.Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells.
P2860
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P2860
Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Differences in the molecular m ...... the unfolded protein response.
@en
Differences in the molecular m ...... the unfolded protein response.
@nl
type
label
Differences in the molecular m ...... the unfolded protein response.
@en
Differences in the molecular m ...... the unfolded protein response.
@nl
prefLabel
Differences in the molecular m ...... the unfolded protein response.
@en
Differences in the molecular m ...... the unfolded protein response.
@nl
P2093
P2860
P356
P1476
Differences in the molecular m ...... the unfolded protein response.
@en
P2093
Alain Bruhat
Andreas M Reimold
Julien Averous
Michael S Kilberg
Pierre Fafournoux
Valérie Carraro
P2860
P304
48107-48114
P356
10.1074/JBC.M206149200
P407
P577
2002-09-25T00:00:00Z