Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
about
Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targetsRegenerative therapies for diabetic microangiopathyRenal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathyTherapeutic Modalities in Diabetic Nephropathy: Future Approaches.PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension.The role of Krüppel-like factor 4 in transforming growth factor-β-induced inflammatory and fibrotic responses in human proximal tubule cells.Oxidative stress in diabetes.Emerging drugs for renal failure.Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy.Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy.Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths.The protein kinase C-beta inhibitor, ruboxistaurin, for the treatment of diabetic microvascular complications.Tandem inhibition of PKC in Diαβetic nephropathy: it takes two to tango?Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage.Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications.Angiotensin II-dependent hypertension increases Na transport-related oxygen consumption by the thick ascending limbPKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability.Pathophysiology of the diabetic kidney.Rodent animal models: from mild to advanced stages of diabetic nephropathy.Novel effective drugs for diabetic kidney disease? or not?Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy.The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1.Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways.Future strategies to prevent renal microvascular disease complications in diabetes.Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-ßI and prooxidant enzyme NADPH oxidase.Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice.Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats.Human recombinant ACE2 reduces the progression of diabetic nephropathy.Loss of TIMP3 selectively exacerbates diabetic nephropathy.Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling.Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose.Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C beta II inhibition in a rat model of metabolic syndrome.Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β.Dissociation of renal TGF-beta and hypertrophy in female rats with diabetes mellitus.Association of 276G>T adiponectin gene polymorphism to plasma adiponectin and albuminuria in type 2 diabetic patients.
P2860
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P2860
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@en
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@nl
type
label
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@en
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@nl
prefLabel
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@en
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@nl
P2093
P1433
P1476
Protein kinase C beta inhibiti ...... nce of continued hypertension.
@en
P2093
Bruce E Kemp
Claire Hepper
Darren J Kelly
Kassie Jaworski
Renae M Gow
Richard E Gilbert
Yuan Zhang
P304
P356
10.2337/DIABETES.52.2.512
P407
P577
2003-02-01T00:00:00Z