Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
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The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseasePhosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cellsClass III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane trafficDefective membrane remodeling in neuromuscular diseases: insights from animal modelsTwo PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cellsMTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegansCaenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cellsStructure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidationIn vivo imaging of skeletal muscle in mice highlights muscle defects in a model of myotubular myopathy.Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafishDrosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functionsPI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegansEndosomal phosphoinositides and human diseases.Sorting nexins provide diversity for retromer-dependent trafficking events.Phosphoinositide 3-kinases as accelerators and brakes of autophagy.Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMOThe FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.The VPS34 PI3K negatively regulates RAB-5 during endosome maturation.Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain.Developmental basis for intestinal barrier against the toxicity of graphene oxide.Myotubularins and associated neuromuscular diseases
P2860
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P2860
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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name
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@en
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@nl
type
label
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@en
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@nl
prefLabel
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@en
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@nl
P2093
P2860
P356
P1476
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
@en
P2093
Ann M Rose
Edward Y Skolnik
Hanna Fares
Yingzi Xue
P2860
P304
34380-34386
P356
10.1074/JBC.M303259200
P407
P577
2003-06-04T00:00:00Z