Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2.

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Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2.

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http://www.wikidata.org/entity/Q46418279

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

@wuu

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

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2017年學術文章

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2017年學術文章

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name

Evaluation of the Utility of C ...... odium-Glucose Cotransporter 2.

@en

Evaluation of the Utility of C ...... lites of a Selective Inhibitor

@nl

type

Item

label

Evaluation of the Utility of C ...... odium-Glucose Cotransporter 2.

@en

Evaluation of the Utility of C ...... lites of a Selective Inhibitor

@nl

prefLabel

Evaluation of the Utility of C ...... odium-Glucose Cotransporter 2.

@en

Evaluation of the Utility of C ...... lites of a Selective Inhibitor

@nl

P1476

Evaluation of the Utility of C ...... Sodium-Glucose Cotransporter 2

@en

P2093

Naoyuki Nakada

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P2860

Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide

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Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.

Why do metabolites circulate?

Medicinal chemistry of drugs with active metabolites (N-, O-, and S-desalkylation and some specific oxidative alterations).

Medicinal chemistry of drugs with active metabolites following conjugation.

Near completely humanized liver in mice shows human-type metabolic responses to drugs.

Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

P304

874-886

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P31

scholarly article

P356

10.1007/S11095-017-2116-4

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Naoyuki Nakada

P577

2017-02-13T00:00:00Z

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P698

28194636

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