The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.
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Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutationsCharacterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanomaA methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancerPromoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinomaStrong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-cateninChemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae6-thioguanine: a drug with unrealized potential for cancer therapy.Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in MiceGenome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous neviExpression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.Detailed characterization of alterations of chromosomes 7, 9, and 10 in glioblastomas as assessed by single-nucleotide polymorphism arrays.Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.Emerging drugs for mesothelioma.A potential predictive marker for response to interferon in malignant melanoma.Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategiesSuppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cellsIncreasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.Deletion of dinucleotide repeat (Delta 14 allele) in the methylthioadenosine phosphorylase (MTAP) promoter and the allelotype of MTAP promoter in the Japanese population.Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines.Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y)CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia.Molecular characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase-deficient mutant clones of murine lymphoma cell line R1.1.Chromosomal and genetic abnormalities in benign and malignant meningiomas using DNA microarray.Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.
P2860
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P2860
The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@en
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@nl
type
label
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@en
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@nl
prefLabel
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@en
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@nl
P2093
P2860
P1476
The methylthioadenosine phosph ...... te type adult T-cell leukemia.
@en
P2093
C J Carrera
D A Carson
M Tomonaga
S Kamihira
P2860
P356
10.1002/(SICI)1097-0215(19980105)75:1<51::AID-IJC9>3.0.CO;2-0
P577
1998-01-01T00:00:00Z