Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP.
about
A key amino acid responsible for substrate selectivity of monoamine oxidase A and BBenzylamine analog binding studies as probes of the substrate sites of monoamine oxidases A and B.Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease.Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondriaMALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.Liquid chromatographic-electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP+) in discrete regions of murine brain.Role of astrocytes in MPTP metabolism and toxicity.Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.Clues to the mechanism underlying dopamine cell death in Parkinson's diseaseMPTP effects on dopamine neurons.Aminium cation radical mechanism proposed for monoamine oxidase B catalysis: are there alternatives?Oxidative stress in Parkinson's disease.Selective and nonselective effects of 1-methyl-4-phenylpyridinium on oxygen consumption in rat striatal and hippocampal slices.Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B.Potentiation by the tetraphenylboron anion of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its pyridinium metabolite.Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines.Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrodeInhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles.Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases.Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Further insight into the mode of action of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Oxidation of tertiary amines by monoamine oxidases.Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine oxidase B.Monoamine oxidase-B in astrocytes.Increased striatal lipid peroxidation after intracerebroventricular MPP+ administration to mice.Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+.Quantitation of a mitochondrial DNA deletion in Parkinson's disease.[3H]1-methyl-4-phenyl-2,3-dihydropyridinium ion binding sites in mouse brain: pharmacological and biological characterization.Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment.
P2860
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P2860
Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh-hant
name
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@en
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@nl
type
label
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@en
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@nl
prefLabel
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@en
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@nl
P2093
P921
P1476
Oxidation of the neurotoxic am ...... vation of the enzymes by MPTP.
@en
P2093
Castagnoli N Jr
P304
P356
10.1016/0006-291X(84)90614-4
P407
P577
1984-12-01T00:00:00Z