Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit.
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Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel stateExon silencing by UAGG motifs in response to neuronal excitationProtein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunitsTargeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxationEthanol and protein kinase C.Low dose acute alcohol effects on GABA A receptor subtypesEthanol actions on multiple ion channels: which are important?Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunitEthanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation.Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors.Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes.The role of GABAA receptors in mediating the effects of alcohol in the central nervous system.Phorbol ester reduces ethanol excitation of dopaminergic neurons of the ventral tegmental area: involvement of protein kinase C thetaLow ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.Insights into the structure and pharmacology of GABA(A) receptors.Use of transgenics, null mutants, and antisense approaches to study ethanol's actions.Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function.Effects of moderate alcohol consumption on the central nervous system.Functional modulation of ligand-gated GABAA and NMDA receptor channels by phosphorylation.Investigation of ethanol-induced impairment of spatial memory in gamma2 heterozygous knockout mice.GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.Differential effects of ethanol on GABA(A) and glycine receptor-mediated synaptic currents in brain stem motoneurons.The role of protein kinase C in cellular tolerance to ethanol.Ethanol alters the subcellular localization of cAMP-dependent protein kinase and protein kinase C.Altered GABA(A)-benzodiazepine receptor number and pharmacology in the adult guinea pig cerebral cortex after chronic prenatal ethanol exposure.Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells.Recombinant GABAA receptor function and ethanol.Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons.Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization.Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat hippocampal CA1 pyramidal neurons.New insight into the mechanisms of ethanol effects on GABAA receptor function and expression, and their relevance to behavior.Mutation of putative phosphorylation sites in the 5-hydroxytryptamine3 receptor does not eliminate its modulation by ethanol.Modulation of GABAA receptor function by alcohols: effects of subunit composition and differential effects of ethanol.Transfected cells for study of alcohol actions on GABA(A) receptors.Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
P2860
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P2860
Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit.
description
1992 nî lūn-bûn
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1992年の論文
@ja
1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年学术文章
@zh-hans
1992年学术文章
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1992年学术文章
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1992年學術文章
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name
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@en
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@nl
type
label
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@en
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@nl
prefLabel
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@en
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@nl
P2860
P1433
P1476
Ethanol potentiation of GABAA ...... ariant of the gamma 2 subunit.
@en
P2093
Wafford KA
Whiting PJ
P2860
P304
P356
10.1016/0014-5793(92)81424-K
P407
P577
1992-11-01T00:00:00Z